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"Drugs that target the noradrenaline system have already been developed for depression and attention deficit hyperactivity disorder (ADHD).
"The researchers say their work suggests they might also help people with Down's syndrome."
Researchers include:Dr Ahmad Salehi, lead researcher
Dr Melanie Manning
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… of {beta}? Amyloid Precursor Protein and Ubiquitin-B in Alzheimer's and Down PatientsScience, 1998 - sciencemag.org.The cerebral cortex of Alzheimer's and Down syndrome patients is characterized by the presence of protein deposits in neurofibrillary tangles, neuritic plaques, and neuropil threads.
Synaptic structural abnormalities in the Ts65Dn mouse model of Down Syndrome. PV Belichenko, E Masliah, AM Kleschevnikov, … - The Journal of Comparative Neurology, 2004 - interscience.wiley.com. The Ts65Dn mouse is a genetic model for Down syndrome.
… cognitive abnormalities in mouse models of Down syndrome: exploring genotype-phenotype …PV Belichenko, AM Kleschevnikov, A Salehi, … - Journal of Comparative Neurology, 2007 - interscience.wiley.com Down syndrome and Ts1Cje mice are segmentally trisomic for a region of mouse chromosome 16, they genetically model DS and are used to study pathogenic mechanisms. (DS) is caused by trisomy of human chromosome 21. Because Ts65Dn
… retrograde transport of NGF in a mouse model of Down's syndrome: reversal of cholinergic …JD Cooper, A Salehi, JD Delcroix, CL Howe, … - Proceedings of the National Academy of Sciences, 2001 - National Acad Sciences. Age-related degeneration of basal forebrain cholinergic neurons (BFCNs) contributes to cognitive decline in Alzheimer's disease and Down's syndrome.
Using mouse models to explore genotype-phenotype relationship in Down syndromeA Salehi, M Faizi, PV Belichenko, WC Mobley - Mental Retardation and Developmental Disabilities …, 2007 - interscience.wiley.com. Down Syndrome (DS) caused by trisomy 21 is characterized by a variety of phenotypes and involves multiple organs.
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